{"id":4167,"date":"2026-04-21T14:09:54","date_gmt":"2026-04-21T11:09:54","guid":{"rendered":"https:\/\/www.docdrmuratkanlioz.com\/en\/?p=4167"},"modified":"2026-04-21T14:09:54","modified_gmt":"2026-04-21T11:09:54","slug":"the-importance-of-donor-selection-in-fecal-transplantation-fmt","status":"publish","type":"post","link":"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/","title":{"rendered":"The Importance of Donor Selection in Fecal Transplantation (FMT)"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_73 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u0130\u00e7indekiler<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#The_Importance_of_Donor_Selection_in_Fecal_Microbiota_Transplantation_FMT\" title=\"The Importance of Donor Selection in Fecal Microbiota Transplantation (FMT)\">The Importance of Donor Selection in Fecal Microbiota Transplantation (FMT)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#What_Is_Fecal_Transplantation\" title=\"What Is Fecal Transplantation?\">What Is Fecal Transplantation?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#What_Is_Microbial_Flora\" title=\"What Is Microbial Flora?\">What Is Microbial Flora?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#How_Is_Microbial_Flora_Acquired\" title=\"How Is Microbial Flora Acquired?\">How Is Microbial Flora Acquired?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#What_Happens_If_Our_Microbial_Flora_Weakens\" title=\"What Happens If Our Microbial Flora Weakens?\">What Happens If Our Microbial Flora Weakens?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#How_Can_We_Strengthen_Our_Microbial_Flora\" title=\"How Can We Strengthen Our Microbial Flora?\">How Can We Strengthen Our Microbial Flora?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#What_Can_Be_Done_If_Our_Microbial_Flora_Is_Weak_and_We_Cannot_Strengthen_It\" title=\"What Can Be Done If Our Microbial Flora Is Weak and We Cannot Strengthen It?\">What Can Be Done If Our Microbial Flora Is Weak and We Cannot Strengthen It?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#What_Are_the_Donor_Selection_Criteria_in_FMT_Treatment\" title=\"What Are the Donor Selection Criteria in FMT Treatment?\">What Are the Donor Selection Criteria in FMT Treatment?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#Can_Anyone_Be_an_FMT_Donor\" title=\"Can Anyone Be an FMT Donor?\">Can Anyone Be an FMT Donor?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#What_Is_Donor_Biodiversity\" title=\"What Is Donor Biodiversity?\">What Is Donor Biodiversity?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#How_Can_FMT_Treatment_Increase_the_Patients_Biodiversity\" title=\"How Can FMT Treatment Increase the Patient&#8217;s Biodiversity?\">How Can FMT Treatment Increase the Patient&#8217;s Biodiversity?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#Why_Do_We_Want_to_Increase_Biodiversity_in_FMT_Treatment\" title=\"Why Do We Want to Increase Biodiversity in FMT Treatment?\">Why Do We Want to Increase Biodiversity in FMT Treatment?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#Is_Genetic_Relatedness_Between_Donor_and_Patient_Required\" title=\"Is Genetic Relatedness Between Donor and Patient Required?\">Is Genetic Relatedness Between Donor and Patient Required?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#Do_the_Donor_and_Patient_Need_to_Be_the_Same_Gender\" title=\"Do the Donor and Patient Need to Be the Same Gender?\">Do the Donor and Patient Need to Be the Same Gender?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#Why_Do_We_Ask_Patients_to_Find_Their_Own_Donor\" title=\"Why Do We Ask Patients to Find Their Own Donor?\">Why Do We Ask Patients to Find Their Own Donor?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#How_Many_Types_of_FMT_Are_There_Based_on_the_Material_Used\" title=\"How Many Types of FMT Are There Based on the Material Used?\">How Many Types of FMT Are There Based on the Material Used?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#Which_FMT_Is_the_Most_Effective_Based_on_the_Material_Used\" title=\"Which FMT Is the Most Effective Based on the Material Used?\">Which FMT Is the Most Effective Based on the Material Used?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#What_Is_the_Most_Important_Donor-Related_Factor_in_FMT_Efficacy\" title=\"What Is the Most Important Donor-Related Factor in FMT Efficacy?\">What Is the Most Important Donor-Related Factor in FMT Efficacy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/#Which_Method_of_Transferring_FMT_Material_to_the_Colon_Is_More_Effective\" title=\"Which Method of Transferring FMT Material to the Colon Is More Effective?\">Which Method of Transferring FMT Material to the Colon Is More Effective?<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"The_Importance_of_Donor_Selection_in_Fecal_Microbiota_Transplantation_FMT\"><\/span><strong>The Importance of Donor Selection in Fecal Microbiota Transplantation (FMT)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"What_Is_Fecal_Transplantation\"><\/span><strong>What Is Fecal Transplantation?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>It is the procedure of transplanting into the patient&#8217;s large intestine a material obtained by processing stool collected from healthy donors with high microbial flora biodiversity in the digestive system. Its abbreviated name in the international literature is FMT (Faecal Microbiota Transplantation).<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_Is_Microbial_Flora\"><\/span><strong>What Is Microbial Flora?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>We coexist with microorganisms \u2014 single-celled, thousands of species, trillions in number, constantly self-renewing, consisting mostly of bacteria, viruses, and yeasts \u2014 that live in peace with us in certain parts of our body. All of these together are called <strong>microbial flora<\/strong>. What we are discussing here is the digestive system flora. We serve as hosts to our <strong><em>Digestive System Flora<\/em><\/strong> and provide their nourishment. Our <strong><em>Digestive System Flora<\/em><\/strong>, in turn, contributes to our antimicrobial defense in all the regions they inhabit, helps maintain moisture and acidity in those regions, enables the digestion of certain foods through enzymatic activities, plays an important role in the synthesis of certain structures (vitamins, etc.), secretes certain neurotransmitters involved in neural signaling, and contributes to countless other vital functions. In short, healthy life without our flora is not possible. We refer to all these microorganisms that settle and reside throughout our digestive system as the <strong><em>digestive system flora<\/em><\/strong>. Each of them has a specific location within the digestive system where they settle and live. Under normal conditions, they do not colonize or survive outside their designated area. Situations such as flora settling outside its designated area, disruption of its composition (dysbiosis, etc.), excessive proliferation in certain regions (SIBO disease, etc.), or an increase in the numbers of certain groups (in obesity cases) are all pathological and each of these is a cause of disease.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_Is_Microbial_Flora_Acquired\"><\/span><strong>How Is Microbial Flora Acquired?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>From birth, we begin to acquire microbial flora from the environment we come into contact with. The nature of the microbial flora acquired during specific developmental periods varies (newborn, adolescent, puberty, pregnancy, old age, etc.). The microbial flora of a healthy individual reaches optimal biodiversity in their twenties. The process that begins with the flora acquired from the mother at birth is further shaped especially by the people most frequently contacted, the foods consumed, and other environmental exposures.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_Happens_If_Our_Microbial_Flora_Weakens\"><\/span><strong>What Happens If Our Microbial Flora Weakens?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>If the biodiversity of our microbial flora decreases \u2014 that is, if it weakens \u2014 it becomes insufficient to contribute to the functions of the region it inhabits, and as a result, absorption and digestive disorders may develop, along with food allergies, infections, dementia, and in later stages, diseases associated with autoimmune processes.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_Can_We_Strengthen_Our_Microbial_Flora\"><\/span><strong>How Can We Strengthen Our Microbial Flora?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>We can introduce new members to our flora, strengthen our existing flora, and protect our current flora by: spending close and prolonged contact with people who have healthier and more biodiverse flora from birth, eating healthily, receiving breast milk for as long as possible, maintaining a natural, adequate, and balanced diet, avoiding processed foods as much as possible, and refraining from unnecessary medication use (especially antibiotics), among other practices.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_Can_Be_Done_If_Our_Microbial_Flora_Is_Weak_and_We_Cannot_Strengthen_It\"><\/span><strong>What Can Be Done If Our Microbial Flora Is Weak and We Cannot Strengthen It?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>If we are unable to strengthen our flora by natural means and the existing flora damage or weakness is causing certain diseases (allergies, nutritional disorders, autoimmune diseases, etc.), the only thing to be done is FLORA TRANSPLANTATION or FECAL TRANSPLANTATION (FMT).<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_Are_the_Donor_Selection_Criteria_in_FMT_Treatment\"><\/span><strong>What Are the Donor Selection Criteria in FMT Treatment?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Donor candidates must meet the exclusion criteria given in Table 1 below and must have a sufficient score as specified in Table 2.<\/p>\n<style>\n.fmt-table-wrap {\n  width: 100%;\n  overflow-x: auto;\n  -webkit-overflow-scrolling: touch;\n  margin: 24px 0;\n}<\/p>\n<p>.fmt-scroll-hint {\n  display: none;\n  font-size: 0.78rem;\n  color: #888;\n  text-align: right;\n  margin-bottom: 4px;\n}<\/p>\n<p>@media (max-width: 680px) {\n  .fmt-scroll-hint { display: block; }\n}<\/p>\n<p>.fmt-table-title {\n  font-weight: bold;\n  font-size: 0.97rem;\n  background: #1a4a6b;\n  color: #fff;\n  padding: 10px 14px;\n  border-radius: 4px 4px 0 0;\n}<\/p>\n<p>.fmt-table {\n  width: 100%;\n  border-collapse: collapse;\n  font-size: 0.9rem;\n  line-height: 1.7;\n}<\/p>\n<p>\/* Table 1 *\/\n.fmt-table.tablo1 { min-width: 580px; }<\/p>\n<p>.fmt-table.tablo1 thead th {\n  background: #2e7d9e;\n  color: #fff;\n  padding: 10px 12px;\n  text-align: left;\n  border: 1px solid #1a4a6b;\n}<\/p>\n<p>.fmt-table.tablo1 tbody td {\n  vertical-align: top;\n  padding: 12px;\n  border: 1px solid #b8d4e8;\n  background: #fff;\n}<\/p>\n<p>.fmt-table.tablo1 tbody tr:nth-child(even) td {\n  background: #f0f6fb;\n}<\/p>\n<p>\/* Table 2 *\/\n.fmt-table.tablo2 { min-width: 640px; }<\/p>\n<p>.fmt-table.tablo2 th {\n  background: #1a4a6b;\n  color: #fff;\n  padding: 9px 10px;\n  text-align: center;\n  border: 1px solid #16394f;\n  font-size: 0.88rem;\n}<\/p>\n<p>.fmt-table.tablo2 td {\n  padding: 8px 10px;\n  border: 1px solid #b8d4e8;\n  text-align: center;\n  vertical-align: middle;\n  font-size: 0.87rem;\n}<\/p>\n<p>.fmt-table.tablo2 td:first-child {\n  text-align: left;\n  font-weight: 600;\n  background: #ddeef7;\n  white-space: nowrap;\n}<\/p>\n<p>.fmt-table.tablo2 tr:nth-child(even) td { background: #f0f6fb; }\n.fmt-table.tablo2 tr:nth-child(even) td:first-child { background: #cce3f2; }<\/p>\n<p>.fmt-table.tablo2 .puan-cell {\n  background: #fef5f5 !important;\n  font-weight: bold;\n  color: #c0392b;\n  min-width: 80px;\n}<\/p>\n<p>.fmt-table.tablo2 .toplam-row td {\n  background: #1a4a6b !important;\n  color: #fff !important;\n  font-weight: bold;\n  text-align: left !important;\n}<\/p>\n<p>.fmt-table.tablo2 .kalite-row td {\n  background: #f0f6fb !important;\n  text-align: left !important;\n  line-height: 1.9;\n}<\/p>\n<p>.fmt-kaynak {\n  font-size: 0.8rem;\n  color: #666;\n  font-style: italic;\n  margin-top: 6px;\n}\n<\/style>\n<p><!-- TABLE 1 --><\/p>\n<div class=\"fmt-table-wrap\">\n<div class=\"fmt-table-title\">Table 1: Exclusion Criteria for Donor Selection in Total Gastrointestinal Flora Transplantation<\/div>\n<p class=\"fmt-scroll-hint\">\u2190 Scroll to view \u2192<\/p>\n<table class=\"fmt-table tablo1\">\n<thead>\n<tr>\n<th>Criteria for the Last Three Months<\/th>\n<th>Criteria for the Last Six Months<\/th>\n<th>Time-Independent Criteria<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\n          &#8211; Hospitalized individuals<br \/>\n          &#8211; Those receiving intravenous treatment<br \/>\n          &#8211; Those who received live vaccines<br \/>\n          &#8211; Those who used antibiotics<br \/>\n          &#8211; Those who used antifungals<br \/>\n          &#8211; Those who underwent parasite treatment<br \/>\n          &#8211; Those who used antivirals<br \/>\n          &#8211; Those who received dental treatment<br \/>\n          &#8211; Those who underwent surgical procedures<br \/>\n          &#8211; Those with a history of animal bites<br \/>\n          &#8211; Those with open wounds<br \/>\n          &#8211; Those who had diarrhea<br \/>\n          &#8211; Suspected sexual exposure<br \/>\n          &#8211; Those with active infections<br \/>\n          &#8211; Those who gave birth<br \/>\n          &#8211; Travel to high-risk regions\n        <\/td>\n<td>\n          &#8211; Chemotherapy<br \/>\n          &#8211; Radiotherapy<br \/>\n          &#8211; Hormone therapy<br \/>\n          &#8211; Immunosuppressive treatment<br \/>\n          &#8211; Intensive care treatment<br \/>\n          &#8211; Oral STOP exceeding 7 days<br \/>\n          &#8211; Major surgical procedure<br \/>\n          &#8211; Blood transfusion<br \/>\n          &#8211; Those who had HAV infection<br \/>\n          &#8211; Contact with agricultural pesticides\n        <\/td>\n<td>\n          &#8211; Being an HIV carrier (AIDS)<br \/>\n          &#8211; Being a Hepatitis B carrier<br \/>\n          &#8211; Being a Hepatitis C carrier<br \/>\n          &#8211; Those with chronic infectious diseases<br \/>\n          &#8211; BMI below 20 kg\/m\u00b2 (underweight)<br \/>\n          &#8211; BMI above 30 kg\/m\u00b2 (overweight)<br \/>\n          &#8211; Diabetic patients using insulin<br \/>\n          &#8211; Those with autoimmune disease<br \/>\n          &#8211; Ulcerative colitis patients<br \/>\n          &#8211; Crohn&#8217;s disease patients<br \/>\n          &#8211; Celiac disease patients<br \/>\n          &#8211; Those with lactose intolerance<br \/>\n          &#8211; Those diagnosed with digestive system cancer<br \/>\n          &#8211; Those who underwent digestive system surgery (except appendectomy)<br \/>\n          &#8211; Those who received less than 6 months of breast milk<br \/>\n          &#8211; Those diagnosed with Leaky Gut Syndrome (LGS)<br \/>\n          &#8211; Drug addicts<br \/>\n          &#8211; Alcoholics<br \/>\n          &#8211; Healthcare workers<br \/>\n          &#8211; Sex workers<br \/>\n          &#8211; Homosexuals<br \/>\n          &#8211; Those over 50 years of age<br \/>\n          &#8211; Schizophrenics<br \/>\n          &#8211; Autistic individuals<br \/>\n          &#8211; Toxic industrial workers<br \/>\n          &#8211; Pregnant women<br \/>\n          &#8211; Oral feeding cessation exceeding three weeks\n        <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"fmt-kaynak\">*Source: Kanlioz M, Ekici U, Ferhato\u011flu MF. Total Gastrointestinal Flora Transplantation in the Treatment of Leaky Gut Syndrome and Flora Loss. Cureus. 2022 Nov 3;14(11):e31071. doi: 10.7759\/cureus.<\/p>\n<p><!-- TABLE 2 --><\/p>\n<div class=\"fmt-table-wrap\">\n<div class=\"fmt-table-title\">Table 2: Donor Quality Scoring<\/div>\n<p class=\"fmt-scroll-hint\">\u2190 Scroll to view \u2192<\/p>\n<table class=\"fmt-table tablo2\">\n<thead>\n<tr>\n<th>CRITERION<\/th>\n<th colspan=\"4\">SCORE<\/th>\n<th>Donor Score<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Age (years)<\/td>\n<td>0\u201320 yrs \u2192 5<\/td>\n<td>21\u201330 yrs \u2192 4<\/td>\n<td>31\u201340 yrs \u2192 3<\/td>\n<td>41\u201350 yrs \u2192 2 | 50+ yrs \u2192 1<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Breast Milk (months)<\/td>\n<td>1\u20136 mo\u2193 \u2192 6<\/td>\n<td>6 mo\u2191 \u2192 9<\/td>\n<td>9 mo\u2191 \u2192 12<\/td>\n<td>12 mo\u2191 \u2192 15 | 24 mo\u2191 \u2192 18<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Place of Residence<\/td>\n<td>Rural \u2192 10<\/td>\n<td colspan=\"2\">Urban \u2192 3<\/td>\n<td>Metropolis \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Chemotherapy<\/td>\n<td>None \u2192 10<\/td>\n<td colspan=\"3\">Received \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Radiotherapy<\/td>\n<td>None \u2192 10<\/td>\n<td colspan=\"3\">Received \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Hormone Therapy<\/td>\n<td>None \u2192 10<\/td>\n<td colspan=\"3\">Received \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Antibiotics 3+ Weeks<\/td>\n<td>None \u2192 10<\/td>\n<td colspan=\"3\">Received \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Immunosuppressive Therapy<\/td>\n<td>None \u2192 10<\/td>\n<td colspan=\"3\">Received \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Oral Feeding Cessation<\/td>\n<td>None \u2192 10<\/td>\n<td colspan=\"2\">\u22647 days \u2192 5<\/td>\n<td>7+ days \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Intensive Care Treatment<\/td>\n<td>None \u2192 10<\/td>\n<td colspan=\"2\">\u22647 days \u2192 5<\/td>\n<td>7+ days \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>History of Diabetes<\/td>\n<td>None \u2192 10<\/td>\n<td colspan=\"2\">Prediabetes \u2192 3<\/td>\n<td>Diabetes \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Allergic Disease<\/td>\n<td colspan=\"2\">None \u2192 5<\/td>\n<td colspan=\"2\">Present \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Autoimmune Disease<\/td>\n<td colspan=\"2\">None \u2192 5<\/td>\n<td colspan=\"2\">Present \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Family History of Autoimmune Disease<\/td>\n<td colspan=\"2\">None \u2192 2<\/td>\n<td colspan=\"2\">Present \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Industrial Food Consumption<\/td>\n<td>None \u2192 5<\/td>\n<td colspan=\"2\">Very rare \u2192 2<\/td>\n<td>Present \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>History of Dysentery<\/td>\n<td>None \u2192 5<\/td>\n<td colspan=\"2\">\u22643 \u2192 2<\/td>\n<td>\u22654 \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>History of Gastroenteritis<\/td>\n<td>None \u2192 5<\/td>\n<td colspan=\"2\">\u22645 \u2192 2<\/td>\n<td>\u22656 \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>GI Surgery<\/td>\n<td colspan=\"2\">None \u2192 10<\/td>\n<td colspan=\"2\">Present \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Chronic Medication Use<\/td>\n<td colspan=\"2\">None \u2192 5<\/td>\n<td colspan=\"2\">Present \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Nutritional Disorder<\/td>\n<td colspan=\"2\">None \u2192 10<\/td>\n<td colspan=\"2\">Present \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr>\n<td>Alcohol Use<\/td>\n<td>None \u2192 10<\/td>\n<td colspan=\"2\">Rarely \u2192 2<\/td>\n<td>Very frequent \u2192 0<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr class=\"toplam-row\">\n<td colspan=\"5\">TOTAL SCORE:<\/td>\n<td class=\"puan-cell\"><\/td>\n<\/tr>\n<tr class=\"kalite-row\">\n<td colspan=\"5\">\n          <strong>DONOR QUALITY BY SCORE<\/strong><br \/>\n          \u2605 125 points and above: Ideal Donor<br \/>\n          \u2605 100\u2013124 points: Very Good Donor<br \/>\n          \u2605 90\u201399 points: Good Donor<br \/>\n          \u2605 80\u201389 points: Acceptable Donor<br \/>\n          \u2605 70\u201379 points: Poor Quality Donor<br \/>\n          \u2605 69 points and below: Very Poor Quality Donor\n        <\/td>\n<td class=\"puan-cell\" style=\"text-align:center; vertical-align:middle;\"><strong>Total Donor Score:<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"fmt-kaynak\">*Source: Kanlioz M, Ekici U, Ferhato\u011flu MF. Total Gastrointestinal Flora Transplantation in the Treatment of Leaky Gut Syndrome and Flora Loss. Cureus. 2022 Nov 3;14(11):e31071. doi: 10.7759\/cureus.<\/p>\n<p>First and foremost, the donor candidate must be healthy and must not have taken antibiotics, probiotics, or alcohol within the last three weeks prior to transplantation. Standard physical and systemic examinations are performed on donor candidates. Donor candidates who meet these criteria are then evaluated for health status and communicable diseases through a series of blood, urine, and stool tests. Individuals who pass all of these stages may be accepted as donor candidates.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Can_Anyone_Be_an_FMT_Donor\"><\/span><strong>Can Anyone Be an FMT Donor?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Anyone who meets the criteria stated above can be an FMT donor.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_Is_Donor_Biodiversity\"><\/span><strong>What Is Donor Biodiversity?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>It is a term indicating how diverse the components that make up the donor candidate&#8217;s microbial flora are. This can be illustrated most simply as follows: the greater the variety of technical personnel and engineering specialties in a factory, the higher the quality and sophistication of the products manufactured. The human digestive system can be thought of in exactly the same way as a factory. The greater the diversity of our flora, the healthier our digestive system functions will be. High donor biodiversity is a prerequisite sought in a donor candidate. If the donor candidate&#8217;s biodiversity is insufficient, there is no need to proceed to the next stages \u2014 that person cannot be a donor.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_Can_FMT_Treatment_Increase_the_Patients_Biodiversity\"><\/span><strong>How Can FMT Treatment Increase the Patient&#8217;s Biodiversity?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>By transferring microbial flora components that did not previously exist in the patient&#8217;s large intestine, it becomes possible to perform certain functions that could not be carried out in the past, to revive lost functions, and thereby to treat diseases caused by missing flora elements. The acquisition of a flora element that was previously absent in us increases our biodiversity. The acquisition of flora components that were never present in us, or that existed in the past and were lost over time, can be achieved through FMT.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Why_Do_We_Want_to_Increase_Biodiversity_in_FMT_Treatment\"><\/span><strong>Why Do We Want to Increase Biodiversity in FMT Treatment?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>To achieve higher quality and more functional large intestine (colon) function.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Is_Genetic_Relatedness_Between_Donor_and_Patient_Required\"><\/span><strong>Is Genetic Relatedness Between Donor and Patient Required?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>No.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Do_the_Donor_and_Patient_Need_to_Be_the_Same_Gender\"><\/span><strong>Do the Donor and Patient Need to Be the Same Gender?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>No.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Why_Do_We_Ask_Patients_to_Find_Their_Own_Donor\"><\/span><strong>Why Do We Ask Patients to Find Their Own Donor?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Knowing the donor candidate&#8217;s past life history is important for evaluating the Table 1 criteria more reliably. It is important for us to more accurately assess the dietary habits, alcohol, drug, and tobacco dependencies, and past illnesses of a person whose background we know.<\/p>\n<p>Another consideration is that the most effective way to eliminate the patient&#8217;s questions about the donor is for the patient to find the donor candidate themselves.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_Many_Types_of_FMT_Are_There_Based_on_the_Material_Used\"><\/span><strong>How Many Types of FMT Are There Based on the Material Used?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>&#8211; <strong>Fresh FMT (Real-Time FMT):<\/strong> Stool collected from the donor is processed in the shortest possible time and transferred to the patient&#8217;s large intestine. The time involved here is approximately 30\u201360 minutes. Performing the transplant in the shortest possible time is the most important factor in increasing the success of FMT treatment.<\/p>\n<p>&#8211; <strong>Frozen FMT:<\/strong> FMT samples collected from healthy donor candidates are stored at -40<sup>0<\/sup>C. They are retrieved and used when needed.<\/p>\n<p>&#8211; <strong>Capsule FMT:<\/strong> FMT material is placed inside a capsule form. Patients swallow these capsules orally with water to allow them to reach the intestines. The capsules are produced in a form that opens in the intestine.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Which_FMT_Is_the_Most_Effective_Based_on_the_Material_Used\"><\/span><strong>Which FMT Is the Most Effective Based on the Material Used?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>The most effective method is Fresh (Real-Time) FMT. This is because what we are transferring here are living microorganisms. They must reach the large intestine while maintaining their viability and with the least possible damage. The most effective method for this is Fresh FMT.<\/p>\n<p>Frozen FMT has lower efficacy compared to Fresh FMT.<\/p>\n<p>Capsule FMT has the least efficacy among these methods.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_Is_the_Most_Important_Donor-Related_Factor_in_FMT_Efficacy\"><\/span><strong>What Is the Most Important Donor-Related Factor in FMT Efficacy?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Beyond the donor&#8217;s health criteria, the most important factor is the donor&#8217;s biodiversity and the application of the FMT method using the greatest possible number of donors.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Which_Method_of_Transferring_FMT_Material_to_the_Colon_Is_More_Effective\"><\/span><strong>Which Method of Transferring FMT Material to the Colon Is More Effective?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>FMT material is transferred to the colon by the following methods:<\/p>\n<p>&#8211; Rectal Enema Method<br \/>\n&#8211; Colonoscopy Method<br \/>\n&#8211; Endoscopy Method<br \/>\n&#8211; Endoscopy and Colonoscopy Method<br \/>\n&#8211; Oral Capsule Method<\/p>\n<p>Among these methods, the simultaneous use of both endoscopy and colonoscopy to transfer FMT material to multiple sites provides the most successful outcomes from FMT treatment.<\/p>\n<p><strong>Assoc. Prof. Dr. Murat KANLI\u00d6Z<\/strong><\/p>\n<p><strong>General Surgery Specialist<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Importance of Donor Selection in Fecal Microbiota Transplantation (FMT) What Is Fecal Transplantation? It is the procedure of transplanting into the patient&#8217;s large intestine a material obtained by processing stool collected from healthy donors with high microbial flora biodiversity in the digestive system. Its abbreviated name in the international literature is FMT (Faecal Microbiota &hellip; <a href=\"https:\/\/www.docdrmuratkanlioz.com\/en\/the-importance-of-donor-selection-in-fecal-transplantation-fmt\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">The Importance of Donor Selection in Fecal Transplantation (FMT)<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":4169,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-4167","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/posts\/4167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/comments?post=4167"}],"version-history":[{"count":1,"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/posts\/4167\/revisions"}],"predecessor-version":[{"id":4168,"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/posts\/4167\/revisions\/4168"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/media\/4169"}],"wp:attachment":[{"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/media?parent=4167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/categories?post=4167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.docdrmuratkanlioz.com\/en\/wp-json\/wp\/v2\/tags?post=4167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}